Citalopram has no or quite low fondness for 5-HT1A, 5-HT2A, dopamine D1 as well as D2, α1-, α2-, and also ß-adrenergic, histamine H1, gamma aminobutyric acid (GABA), muscarinic cholinergic, and also benzodiazepine receptors. Antagonism of muscarinic, adrenergic and histaminergic receptors has been hypothesized to be linked with various anticholinergic, sedative, and also cardiovascular effects of other psychotropic medicines.
The single- as well as multiple-dose pharmacokinetics of citalopram are linear as well as dose-proportional in a dosage range of 10 to 60 mg/day. Biotransformation of citalopram is primarily hepatic, with a mean incurable half-life of concerning 35 hours. With once everyday application, steady state plasma concentrations are achieved within roughly one week. At steady state, the level of buildup of citalopram in plasma, based on the half-life, is expected to be 2.5 times the plasma focus observed after a single dose. The tablet and oral option dosage forms of citalopram hydrobromide are bioequivalent.
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Following a solitary dental dose (40 milligrams tablet) of citalopram, peak blood levels happen at around 4 hours. The downright bioavailability of citalopram had to do with 80 % relative to an intravenous dose, and also absorption is not had an effect on by food. The volume of distribution of citalopram has to do with 12 L/kg and also the binding of citalopram (CT), demethylcitalopram (DCT) and also (DDCT) to human plasma healthy proteins is regarding 80 %.